Endocrine Abstracts

Introduction: Faster decline in serum thyroid hormone levels in hyperthyroidism is seen adding cholestyramine at conventional treatment in some studies (1.2).Design/methods: Retrospective controlled study. Follow-up: ±3 weeks.Patients with hyperthyroidism: 17 treated with antithyroid drugs (mean dose 35 mg/day) combined with cholestyramine (mean dose 12 g/day).Control group: 23 only treated with antithyr...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a benign disorder, with inappropriately elevated parathyroid hormone, without the complications of hypercalcemia (1). It is important to discriminate FHH from primary hyperparathyroidism (PHPT), because of the consequences on symptomatic disease and therapeutic approach. Ca/Cr clearance ratio will be <0.01 in FHH and most often >0.02 in PHPT (2). In patients with PHPT and vitamin D deficiency, low urinary calc...

Introduction: Pituitary lesions are quite often in the general population and can be symptomatic or not. Most are attributed to pituitary adenomas. Differential diagnosis also includes other causes, such as granulomatous diseases (sarcoidosis, histiocyttosis). Neurosarcoidosis is rare. Sarcoidosis pituitary infiltration is even more rare and usually reported in multifocal forms of the disease.Case report: We describe a 34-year old female with headache an...

Introduction: Neuroendocrine tumors (NETs) are a heterogeneous group of rare neoplasms that originate from endocrine cells with the ability to secrete amines and hormonal polypeptides. Pancreatic neuroendocrine tumors (PNETs) can be functional or non-functional. Functional PNETs secrete common hormones such as gastrin, insulin and glucagon and much less frequent hormones such as vasoactive intestinal peptide (VIP). Their clinical characteristics depend on the peptide secreted....

Introduction: Medullary thyroid carcinoma (MTC) accounts for 1-5% of all thyroid cancers. It is a neuroendocrine tumor arising from the calcitonin-secreting parafollicular cells of the thyroid. In rare cases, the neoplastic cells additionally secrete other substances, such as histamine, serotonin, ACTH, CRF etc, leading to paraneoplastic syndromes.Case report: An 80 year old male presented to our Department with an already diagnosed metastatic MTC. Three...

Introduction: During embryogenesis the descent of the thyroid may not proceed normally and may stop at various sites from the base of the tongue to any site of the thyroglossal duct.Ectopic thyroid tissue, defined as thyroid tissue not located at its normal site (anterolaterally to the second and fourth tracheal cartilages) is rare. Most often, ectopic tissue is located in the base of the tongue.Case report: We report a 75-year old...

Introduction: Resistance to thyroid Hormones (RTH) is a syndrome characterized by reduced tissue responsiveness to thyroid hormones (TH).This results to constantly elevated levels of TSH despite high levels of free T3 (FT3) and free T4 (FT4).RTH is due to mutations of the gene encoding the b-isoform of the receptor of TH (THR-b gene), inherited in the autosomal dominant manner.Clinical expression of RTH varie...

Background and aims: To evaluate the evolution of thyroid cancer epidemiological characteristics from 2004 to 2014.Materials and methods: Retrospective analysis of histological data from thyroidectomies performed in our hospital in the period 2004–2014.Results: From 2004 to 2014, 2725 thyroidectomies (women 81% vs men 19%) were performed in our hospital. In 1083 of these (40%) histologic examination revealed thyroid cancer.</p...

The glucagon-like peptide-1 receptor (GLP-1R) is a G protein-coupled receptor (GPCR) expressed in various tissues such as brain and pancreas where it contributes to the regulation of energy expenditure and metabolism. Due to its involvement in glucose-dependent release of insulin from pancreatic beta cells, the GLP-1R has become a blockbuster target for the treatment of type 2 diabetes. Despite this, debate still exists about the exact distribution of the GLP-1R throughout the...